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What is Opana ER?

Opana (oxymorphone) is an opioid pain reliever. Oxymorphone extended-release helps relieve severe ongoing pain. It belongs to the long-acting opioid analgesics class of drugs. You should not use the extended-release form of oxymorphone to ease the mild or that will go away in a few days. 

Important Information

Never take this drug if you have severe asthma or breathing problems, a blockage in your stomach or intestines, or moderate to severe liver disease.

Oxymorphone has the potential to slow or stop your breathing and may become habit-forming. Addiction, overdose, or death may result from the misuse of Opana, especially in a child patient or other person using this drug without a prescription.

Opana use during pregnancy can result in life-threatening withdrawal symptoms in the newborn.

Fatal side effects may occur if you take Opana with alcohol or other drugs that cause drowsiness or slow breathing.

What to know before taking Opana ER?

Do not take Opana if you are allergic to oxymorphone, or if you have:

  • Severe liver disease
  • Severe asthma or breathing problems
  • A stomach or bowel obstruction

To make sure Opana is suitable for you, tell your doctor if you have ever had:

  • A head injury or seizures
  • Urination problems
  • Liver or kidney problems
  • Breathing problems, sleep apnea ( that stops breathing during sleep)
  • Drug or alcohol addiction, or mental illness
  • Problems with your gallbladder, pancreas, or thyroid

If you use Opana while pregnant, your baby may become dependent on the drug. It may result in life-threatening withdrawal symptoms in the baby after birth. Babies born addicted to opioids may require medical care for several weeks.

If you are breastfeeding, consult your health advisor before using Opana. Inform your doctor if you notice the nursing baby is tired or breathing slowly.

How to take Opana ER?

Take Opana as prescribed by your doctor. Read all medication guides and follow the directions on your prescription label. Do not use Opana in more significant amounts or for longer than prescribed. 

Never give Opana to someone else, especially someone who has a history of drug abuse or addiction. Addiction, overdose, or death may result from the misuse of Opana, especially in a child patient or other person using the medication without a prescription by a health advisor. It is illegal to sell or distribute Opana ER. However, you can order Opana ER online.

When you start taking Opana, you should stop using all around-the-clock opioid pain relievers.

You can take Opana on an empty stomach at least 1 hour before or 2 hours after a meal.

Take Opana ER at the same time every day.

To prevent a potentially fatal overdose, swallow the tablet whole. Do not chew, crush, break, or dissolve.

Take only one Opana ER extended-release tablet at a time. Do not lick or wet the tablets before placing them in your mouth to avoid choking. 

Never crush or break this drug pill to inhale the powder or mix it into a liquid to inject the drug into a vein. It has the potential to result in death.

If you stop using Opana abruptly after prolonged use, you may experience unpleasant withdrawal symptoms. Inquire with your doctor about the safest way to discontinue Opana.

Store away from moisture, heat, and light at room temperature. Keep a record of your medications. You should be aware if someone is misusing it or using it without a prescription.

Do not save any leftover opioid medication. A single dose of this medication can be fatal if taken accidentally or improperly.

Opana ER dosage

Adult Dose of Opana ER for Chronic Pain:

Please take it as the first opioid analgesic or for patients who are not taking narcotic medicines: The initial dose for extended-release tablets is 5 mg orally every 12 hours. 


Overdose of oxymorphone can be fatal, especially in children or others who use the medication without a prescription. Overdose can cause severe drowsiness, pinpoint pupils, slow breathing, or no breathing at all.

Your doctor may advise you to obtain naloxone (a medication to reverse an opioid overdose) and keep it with you at all times. If you stop breathing or do not wake up, someone caring for you can administer naloxone. Your caregiver must still seek emergency medical assistance and may need to perform CPR (Cardiopulmonary Resuscitation) on you while waiting for help.

What to avoid while using Opana ER?

Never drink alcohol while using Opana ER. Dangerous side effects or death could occur.

Avoid driving or doing dangerous activities until you know how this medication will affect you. Dizziness and drowsiness can lead to falls, accidents, and serious injuries.

Opana ER side effects

Opioid medication can slow or stop your breathing which can be fatal. If you have blue lips, slow breathing with long pauses, or are difficult to wake up, someone caring for you should administer naloxone and seek emergency medical attention.

Common side effects of Opana may include:

  • Headache, tiredness
  • Dizziness, drowsiness
  • Stomach pain, nausea, vomiting, constipation

Serious side effects

  • A light-headed feeling such as might pass out
  • Weak or shallow breathing, breathing that stops
  • Seizure (convulsions)
  • Severe vomiting
  • Chest ache, wheezing, cough with yellow or green mucus
  • High levels of serotonin in the body, symptoms may include agitation, hallucinations, fever, sweating, shivering, fast heartbeat, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea
  • Low cortisol levels, including symptoms such as nausea, vomiting, loss of appetite, dizziness, worsening tiredness, or weakness

Serious side effects may be more common in older people and overweight, malnourished, or disabled.

What drugs can interact with Opana ER?

Opioid medication can interact with other medicines, resulting in dangerous side effects or death. Make sure your doctor is aware if you also use:

  • Drugs for motion sickness, irritable bowel syndrome, or overactive bladder
  • Cold or allergy medicines, bronchodilator asthma or COPD medication, or a diuretic 
  • Other opioids – opioid pain medication or prescription cough medicine
  • A sedative like Valium, including diazepam, alprazolam, lorazepam, Xanax, Klonopin, Ativan, and many others
  • Drugs that make you sleepy or suffering from breathing problems – a sleeping pill, muscle relaxer, medication to treat mood disorders or mental illness
  • Medicines that can affect serotonin levels in your body – a treatment or stimulant for depression, migraine headaches, Parkinson’s disease, serious infections, or nausea and vomiting

If you want to buy Opana ER online, make sure to check all the drug interactions.