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What is Lorcet?

Lorcet is an opioid that helps relieve pain. It is also available with its generic name hydrocodone bitartrate and acetaminophen tablet. Acetaminophen and hydrocodone function according to their medicinal capacity in relieving pain.

Hydrocodone bitartrate is an antitussive and opioid analgesic and occurs as fine white crystals or as a crystalline powder. At the same time, acetaminophen is a slightly bitter, odorless, white crystalline powder, is a non-salicylate, non-opiate analgesic, and antipyretic.

Hydrocodone present in Lorcet suppresses the cough reflex, as with narcotics, one should use caution while using Lorcet for postoperative pain and in patients with pulmonary disease. 

Important Information

As with any narcotic analgesic drug, you should use Lorcet with caution in debilitated and elderly patients and those with severe impairment of renal or hepatic function, hypothyroidism, Addison’s disease, urethral stricture, or prostatic hypertrophy. Take usual precautions and keep the possibility of respiratory depression in mind.

In patients with severe renal or hepatic disease, the doctor will monitor the effects of therapy with various liver and renal function tests.

What to know before taking Lorcet?

Opioid medication like Lorcet can slow down or stop your breathing, and death may occur. Your attendant should give naloxone to you and get urgent medical help if you have blue-colored lips, slow breathing with long pauses, or if you are hard to wake up. 

You should avoid taking Lorcet if you are allergic to it or any element of this drug or have any medical conditions, including asthma (severe) or breathing problems; or a blockage in the stomach or intestines.

Tell each of your medical healthcare providers if you have ever had any of the following medical conditions:

  • Liver disease;
  • Kidney disease;
  • Urination problems;
  • Sleep apnea, breathing problems;
  • A drug or alcohol addiction;
  • A head injury or seizures; or
  • Problems with your pancreas, thyroid, or gallbladder

If you use an opioid medication like Lorcet during pregnancy, you could give birth to a drug-dependent baby. It can result in life-threatening withdrawal symptoms in the newborn baby. In addition, opioid-dependent babies may need medical treatment for several weeks. 

Ask a doctor before taking Lorcet (or any other opioid medication) if you are breastfeeding. Also, inform the doctor if you notice slow breathing or severe drowsiness in the nursing baby. 

How to take Lorcet?

Read the available medication guide and Patient Information Leaflet before you start taking Lorcet and get a refill each time. If you have any queries regarding dosage, ask your doctor or pharmacist. 

Take Lorcet precisely as per the doctor’s prescription. Read carefully and follow all the directions on the prescription label and medication guides. Never take medicines like Lorcet in larger or smaller amounts or for longer than recommended. 

Take this medication orally as per the doctor’s directions. You may take Lorcet with or without food. If you have nausea, you should take this drug with food. Ask any of your medical health care providers about other ways to reduce nausea (such as lying down for an hour or two with minimum head movement). 

Never share this medicine with someone else, especially someone with a past of drug abuse or addiction. Misuse of Lorcet can cause addiction, overdose, or death. 

Keep the medicine out of reach of others. It is against the lawful act to sell or give away this medication without a proper pharmacy license. 

Store Lorcet away from heat and moisture at room temperature. Keep track of your drug. Be aware of someone misusing your medicine or taking it without a prescription. 

Dispose of leftover opioid medication. Just one accidental or an improper dose of this medicine can prove fatal for someone taking it. 

Carefully measure the liquid medicine. Use the available dosing syringe or a medicine dose-measuring device for convenience in having the exact amount of medication. 

If you require medical tests or surgery, tell the doctor before that you are using this medicine. 

Lorcet dosage

Usual adult dosage of Lorcet oral tablets for pain:

  • Acetaminophen 325 mg- hydrocodone 5 mg per tablet: Initial dose- 1 to 2 pills every four to six hours as needed for pain.
  • The maximum quantity of Lorcet oral pills should not exceed eight tablets a day.


Take medical help immediately or call the Poison helpline at 1-800-222-1222. An overdose of Lorcet can be deadly, especially in a child or someone taking it without a prescription. An overdose can cause liver damage or death. If you are feeling an increased urge to use this medicine, inform your doctor. 

Overdose symptoms to Lorcet may include vomiting, nausea, severe drowsiness, sweating, slow breathing, pinpoint pupils, or no breathing. 

Your doctor may recommend you keep naloxone (a drug to reverse opioid overdose) with you all the time. Anyone can get naloxone from a local health department or pharmacy. Ensure your caretaker knows where you keep it and how to use naloxone. 

What to avoid while using Lorcet?

Avoid driving any vehicle or operating any heavy machinery until you know this medicine’s effect on you. Drowsiness or dizziness can cause accidental falls or severe injuries. 

Avoid consumption of alcohol. It can result in dangerous side effects, or death could occur. 

Ask any of your medical healthcare providers before taking any other drug that may contain acetaminophen (sometimes known as APAP). Taking specific medications together can cause a fatal overdose. Check the label before buying any medicine for cold, allergy, pain, or sleep.

Lorcet side effects

Take urgent medical help if you have an allergic reaction due to the use of Lorcet. Sings of an allergic reaction include trouble breathing, hives, swelling of your face, throat, lips, or tongue. 

Common side effects to Lorcet that do not require immediate medical attention may include headache, vomiting, constipation, dizziness, drowsiness, nausea, stomach pain, or feeling tired.

In rare cases, the use of acetaminophen may result in severe skin reactions that can be fatal. It can happen even if you had acetaminophen (paracetamol) in the past and had no response. Call your doctor instantly and stop taking Lorcet if you have skin redness or rash/hives that spreads and causes blistering and peeling.

Tell medical health care provider promptly if you have any severe side effects, including:

  • Interrupted breathing during sleep;
  • Moodswing or mental changes such as confusion, agitation, hallucinations;
  • Stomach or abdominal pain;
  • Seizure (or convulsions);
  • Fainting;
  • Severe drowsiness, difficulty waking up;
  • Slow or shallow breathing;
  • Difficulty in urination; or
  • Signs of inefficient functioning of adrenal glands such as weight loss, unusual tiredness, loss of appetite; 
  • A light-headed feeling that makes you feel that you might pass out;
  • Shallow breathing, sighing, noisy breathing, breathing that stops;
  • Low cortisol levels- vomiting, nausea, dizziness, loss of appetite, worsening weakness or tiredness;
  • Liver problems- upper stomach pain, nausea, loss of appetite, fatigue, clay-colored stools, dark urine, jaundice (yellowing of the eyes or skin); or
  • High serotonin levels in the body- agitation, fever, hallucinations, shivering, sweating, muscle stiffness, rapid heart rate, loss of coordination, twitching, vomiting, nausea, diarrhea. 

It is not a complete list of side effects, and others may occur. For further information regarding side effects, consult your medical healthcare provider. Report side effects to FDA at 1-800-FDA-1088. 

What drugs can interact with Lorcet?

You may have withdrawal symptoms or breathing problems if you take certain other medicines. Tell your medical healthcare provider if you also use antifungal medication, antibiotics, seizure medication, blood pressure or heart treatment, or medicine to treat hepatitis C or HIV. 

Opioids can interact with various other drugs and cause fatal side effects. Ensure that your doctor knows if you also use:

  • Medicines for overactive bladder, irritable bowel syndrome, or motion sickness;
  • Bronchodilator asthma or COPD (chronic obstructive pulmonary disease) medication, cold or allergy medicines, or a diuretic “water pill”;
  • A sedative like Valium- Versed, Klonopin, Xanax, lorazepam, alprazolam, diazepam, and others;
  • Other opioids- prescription cough medicine or opioid pain drug;
  • Drugs that affect serotonin levels- a stimulant or medicine for nausea and vomiting, serious infections, migraine headaches, depression, or Parkinson’s disease; 
  • Drugs that cause sleepiness or slow down your breathing- medicine to treat mood changes or mental illness, a sleeping pill, a muscle relaxer.

It is not a complete list, and others may also interact with Lorcet, including prescription and over-the-counter (OTC) medicines, herbal products, and vitamins.